P-087: Adalimumab as first-line anti-TNF treatment in pediatric Crohn’s disease

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منابع مشابه

[A real-world study focused on the effectiveness and safety of adalimumab as first-line anti-TNF treatment for pediatric Crohn's disease].

BACKGROUND AND OBJECTIVES Adalimumab (ADA), a monoclonal humanised anti-TNF antibody, is usually prescribed as a second-line treatment in paediatric Crohn's disease (CD) patients who have become unresponsive or developed intolerance to infliximab (IFX). In the case series reported, more than 70% of patients had initially been treated with IFX. Data on short- and long-term effectiveness of ADA i...

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A real-world study focused on the effectiveness and safety of adalimumab as first-line anti-TNF treatment for paediatric Crohn’s disease

a Sección de Gastroenterología y Nutrición Infantil, Hospital Materno Infantil, Málaga, Spain b Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain c Unidad para el Cuidado Integral de la Enfermedad Inflamatoria Intestinal Pediátrica, Sección de Gastroenterología, Hepatología y Nutrición Pediátrica, Hospital Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain d Unidad d...

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Rituximab as a first-line preventive treatment in pediatric NMOSDs

OBJECTIVE No established therapeutic protocol has been proposed to date for childhood-onset neuromyelitis optica (NMO) spectrum disorders (NMOSDs). We report the response of 5 NMO immunoglobulin (Ig)G-positive pediatric cases to a standardized B-cell-targeted first-line immunosuppressive protocol with rituximab for prevention of relapses. METHODS Retrospective observational cohort study. RE...

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P 141: Mesenchymal Stem Cells as Treatment in Neuroinflammatory Disease

Mesenchymal stem cells can be obtained from deferent tissues like adipose tissue, umbilical cord, placenta, skin, bone marrow, etc. These cells have regulatory effects on all types of immune cells such as dendritic cell, natural killers and lymphocytes. Mesenchymal stem cells induce inhibitory phenotypes of Antigen Presenting Cells (APCs) following their activity. They also change T cells pheno...

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Anti-TNF Treatment in Inflammatory Bowel Disease

Crohn’s disease and ulcerative colitis are chronic inflammatory disorders of the gastrointestinal tract. Although the primary etiological defect stil remains unknown, in the last decade impotant progress has been made concerning the immunological basis of the disease. Genetic, environmental and microbial factors result in repeated activation of mucosal immune response. Tumor necrosis factor alp...

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ژورنال

عنوان ژورنال: Journal of Crohn's and Colitis

سال: 2014

ISSN: 1873-9946

DOI: 10.1016/s1873-9946(14)50115-8